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PPIS VS. ANTACIDS (Like Rolaids)

What is the difference between PPIs and Antacids? Antacids neutralize stomach acid and work quickly, but effects last for only 1-3 hours after use.3 PPIs, like Nexium 24HR, work differently by blocking the source of acid production.4 PPIs may take 1-4 days for full effect.10


What’s the difference between PPIs and H2s? Histamine blockers (“H2RAs” or Histamine-2 Receptor Antagonists) only block one of the signals that tell your body to make acid. They start working within 30 minutes, last for up to 12 hours, but become less effective if used repeatedly.5-9
PPIs, like Nexium 24HR, work differently by blocking the source of acid production with just 1 pill every 24 hours.11 PPIs may take 1-4 days for full effect.





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∆ 2018 IQVIA Provoice Survey for OTC PPIs
† 2017 IMS Global OTC Analysis
3. Robinson, M., Rodriguez‐Stanley, S., Miner, P. B., McGuire, A. J., Fung, K., & Ciociola, A. A. (2002). Effects of antacid formulation on postprandial oesophageal acidity in patients with a history of episodic heartburn. Alimentary Pharmacology & Therapeutics, 16(3), 435-44
4. How Nexium Works. (2018). Retrieved from
5. H2 Blockers. (2016). International Foundation for Gastrointestinal Disorders. Retrieved from
6. H2-blockers: Onset time. (n.d.). OpenAnesthesia. Retrieved from
7. McRorie, J. W., Kirby, J. A., & Miner, P. B. (2014). Histamine2-receptor antagonists: rapid development of tachyphylaxis with repeat dosing. World Journal of Gastrointestinal Pharmacology and Therapeutics, 5(2), 57
8. Miner Jr., P. B., Allgood, L. D., & Grender, J. M. (2007). Comparison of gastric pH with omeprazole magnesium 20.6 mg (Prilosec OTC) om famotidine 10 mg (Pepcid AC) bd and famotidine 20 mg bd over 14 days of treatment. Alimentary Pharmacology & Therapeutics, 25(1), 103-109
9. Hurlimann, S., Abbühl, B., Inauen, W., & Halter, F. (1994). Comparison of acid inhibition by either oral high‐dose ranitidine or omeprazole. Alimentary Pharmacology & Therapeutics, 8(2), 193-201
10. Shin, J.M., Sachs G. (2008). Pharmacology of proton pump inhibitors. Current Gastroenterology Reports, Dec; 10(6), 528–534. Retrieved from
11. Dosage and administration for Nexium. (2018). Retrieved from